4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-
MN-64
CAS: 92831-11-3
Molecular Formula: C18H16O2
4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]- - Names and Identifiers
4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]- - Physico-chemical Properties
| Molecular Formula | C18H16O2 |
| Molar Mass | 264.32 |
| Density | 1.152±0.06 g/cm3(Predicted) |
| Melting Point | 63-64 °C(Solv: ethanol (64-17-5)) |
| Boling Point | 389.8±42.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| In vitro study | MN-64 is a potent tankyrase 1 inhibitor, with IC 50 s of 6 nM, 72 nM, 19.1 μM, 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks STF luciferase activity at 200 nM. |
4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.783 ml | 18.917 ml | 37.833 ml |
| 5 mM | 0.757 ml | 3.783 ml | 7.567 ml |
| 10 mM | 0.378 ml | 1.892 ml | 3.783 ml |
| 5 mM | 0.076 ml | 0.378 ml | 0.757 ml |
Last Update：2024-01-02 23:10:35
4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]- - Reference Information
| biological activity | MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 of 6 nM and 72 nM, respectively. |
| Target | Value |
| TNKS1 () | 6 nM |
| TNKS2 () | 72 nM |
Last Update：2024-04-09 21:01:54
![4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-](http://res.chembk.com/assets/str/2d/9/92/92831-11-3.png)
Supplier List
Spot supply
Product Name: MN-64 Visit Supplier Webpage Request for quotationCAS: 92831-11-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: MN-64 Visit Supplier Webpage Request for quotationCAS: 92831-11-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History